The 2025 Oxford Masterclass in Epileptology took place at Corpus Christi College, Oxford, and explored the growing role of big data in epilepsy research and care. Sessions throughout the day covered epidemiology, imaging, genomics, EEG and clinical trials, with speakers including Professors Arjune Sen, Mark Richardson, Andrea Cipriani and Eva Morris. Participants also took part in case discussions on practical applications and ethical considerations. Endorsed by ERN EpiCARE and supported by UCB Pharma, the event fostered collaboration across disciplines in the advancement of epilepsy